Recently, various new nanostructures (e.g. nanoparticles, carbon nanotubes, protein motors, graphene etc) have been utilized as a component for advanced functional devices. However, a major stumbling block holding back their practical applications is a difficulty in massive assembly of such devices. In this talk, we will first present a strategy to mass-produce nanostructure-based hybrid devices, where molecular patterns on solid substrates are utilized to direct the adsorption and alignment of nanostructures to form a desired device structures. Then, we will discuss how this simple strategy can be utilized to fabricate various new hybrid nano-devices such as taste receptor protein-based bioelectronic tongues and carbon nanostructure-based hybrid devices.