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Seminar/Colloquim

PHYSICS/BK21 SEMINAR[09.11.11]

본문


“OBSERVING PROTEIN DYNAMICS AND CONFORMATIONAL
       CHANGES BY ENSEMBLE AND SINGLE-MOLECULE
                FLUORESCENCE SPECTROSCOPY”
  
Ø ♦ Speaker : 김소연 박사[한국표준연구원]  
Ø ♦ Place : Physics Seminar Room (Science Bldg, 3-201)
Ø ♦ Date & Time : Nov, 11(Wed)  3:00  ~  4:00 pm

Abstract
  
Recent developments in single-molecule spectroscopy and imaging help to illustrate
how each molecule works as a component of the network in real time. I will describe
two different biological systems using these techniques,: the dynamics of the bacterial
actin  homologue,  MreB  protein  in  living  Caulobacter  crescentus  cell,  and  the
conformational  changes  of  the  chaperonin  GroEL  and  its  substrate,  the  von
Hippel-Lindau tumor suppressor protein, VHL. Lastly, I will briefly introduce current
efforts to observe how mechanical properties, such as stiffness of an extracellular
matrix (ECM) and  shear  flow,  affect  the  dynamics  of  membrane  type  1matrix
metalloproteinase, MT1-MMP in the eukaryotic endothelial cell.


  
        Contact Person : Prof. Nam Ki Lee (054-279-2097, nklee@postech.ac.kr)
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